Carisoprodol is a precursor of meprobamate (Miltown and Equanil), and meprobamate is one of the three primary metabolites created by hepatic biotransformation. Meprobamate dependency secondary to carisoprodol use continues to be reported with associated drug-seeking behavior and withdrawal symptoms. Withdrawal symptoms are like those seen in withdrawal from barbiturates and include restlessness, anxiety, insomnia, anorexia, and vomiting. Severe withdrawal symptoms have included agitation, hallucinations, seizures, and, rarely, death. Because of this prospect of physical dependency, carisoprodol must be tapered instead of abruptly discontinued following long-term use.
Differences in carisoprodol and meprobamate levels are largely on account of CYP2C19 metabolism. In the urine of an individual considered CYP2C19 poor metabolizers, we might expect elevations in carisoprodol, plus an estimated 50% reduction in meprobamate metabolites.?? Among those that are rapid CYP2C19 metabolizers, we’d expect increased concentrations of carisoprodol online pharmacy and reductions in meprobamate.
Though Soma might be effective with minimal risks more than a short-term, long-term usage may increase incidence of side effects or odds of psychological dependence. Additionally, there is evidence that long-term use of GABAergic agents is linked to dementia and maybe permanent memory impairment. Concerned with long-term implications and potentially failing a drug test, many users discontinue Soma, but wonder just how long it’ll remain in their system.